An intra-articular injection is a type of shot that's placed directly into a joint to relieve pain. Corticosteroids (steroids), local anesthetics, hyaluronic acid, and Botox are the most common substances injected into joints for this treatment.
The most common type of intra-articular knee injection is with corticosteroids, but other agents have been used, including infliximab, hyaluronic acid, botulinum neurotoxin, and platelet-rich plasma (PRP).